【佳学基因检测】褪黑激素在新型多囊肾病果蝇模型中减少囊肿

做基因检测多少钱资源

深究dota2吧雷电竞 分子诊断与基因分析明白《Molecules》在. 2020 Nov 23;25(22):5477.发表了一篇题目为《褪黑激素在新型多囊肾病果蝇模型中减少囊肿》dota2吧雷电竞 dota2吧雷电竞 治疗基因检测临床研究文章。该研究由Cassandra Millet-Boureima, Roman Rozencwaig, Felix Polyak, Chiara Gamberi等完成。促进了dota2吧雷电竞 的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

果蝇,长寿,褪黑激素,氧化应激,多囊肾,肾囊肿

肿瘤靶向治疗基因检测临床应用结果

常染色体显性多囊肾病 (ADPKD) 导致肾小管、肾单位进行性囊性变性，贼终严重损害肾功能。 ADPKD 是无法治好的，有一半的患者贼终需要肾脏置换。 ADPKD 患者的治疗基因解码基因检测的研究方法有限，需要新的有效治疗基因解码基因检测的研究方法。褪黑激素是一种在所有生命王国中保守的中央代谢调节剂，具有肿瘤抑制和肿瘤保护活性，并且未检测到毒性。在这里，基因解码基因检测使用多囊肾病的双尾 C (BicC) 果蝇模型来测试褪黑激素的减少囊肿的潜力。褪黑激素给药后，肾小管（Malpighian）小管囊肿显着减少，表明机制复杂。与脊椎动物 PKD 类似，BicC 苍蝇 PKD 模型对抗增殖药物雷帕霉素和第二种线粒体衍生的半胱天冬酶 (Smac) 激活剂有反应。褪黑激素似乎是一种新的减少囊肿的分子，具有吸引人的特性，可作为 PKD 治疗的潜在候选者。长寿;褪黑激素;氧化应激;多囊肾;肾囊肿。

肿瘤发生与反复转移国际数据库描述：

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment.Keywords: Drosophila; longevity; melatonin; oxidative stress; polycystic kidney disease; renal cysts.