【佳学基因检测】FOXD1 通过调节 GLUT1 介导的有氧糖酵解促进胰腺癌细胞增殖、侵袭和转移

靶向药一般多少钱排名

研究看到《Cell Death Dis》在. 2022 Sep 3;13(9):765.发表了一篇题目为《FOXD1 通过调节 GLUT1 介导的有氧糖酵解促进胰腺癌细胞增殖、侵袭和转移》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Kun Cai #, Shiyu Chen #, Changhao Zhu #, Lin Li, Chao Yu, Zhiwei He, Chengyi Sun等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

肿瘤靶向治疗基因检测临床应用结果

尽管已发现 FOXD1 参与多种癌症的恶性过程，但其在胰腺癌 (PC) 中的作用尚不清楚。本研究旨在探讨FOXD1在PC中的表达和功能。我们发现与非肿瘤组织相比，PC 组织中 FOXD1 的 mRNA 和蛋白表达上调，并且 FOXD1 的高表达水平与 PC 的不良预后指数相关。体外和体内测定结果表明，FOXD1 的过表达促进有氧糖酵解和 PC 细胞增殖、侵袭和转移的能力，而 FOXD1 敲低抑制这些功能。机理实验结果表明，FOXD1不仅可以直接促进SLC2A1的转录，还可以通过RNA诱导的沉默复合物抑制SLC2A1的降解。因此，FOXD1 增强 GLUT1 表达，并贼终通过调节有氧糖酵解促进 PC 细胞增殖、侵袭和转移。总之，FOXD1 被认为是 PC 的潜在治疗靶点。

肿瘤发生与反复转移国际数据库描述：

Although FOXD1 has been found to be involved in the malignant processes of several types of cancers, its role in pancreatic cancer (PC) is not well understood. This study aimed to investigate the expression and function of FOXD1 in PC. We found that FOXD1 mRNA and protein expression were upregulated in PC tissues compared with non-tumor tissues, and high expression level of FOXD1 was associated with an adverse prognostic index of PC. The results of in vitro and in vivo assays indicate that overexpression of FOXD1 promotes aerobic glycolysis and the capacity of PC cells to proliferate, invade, and metastasize, whereas FOXD1 knockdown inhibits these functions. The results of mechanistic experiments suggest that FOXD1 can not only directly promote SLC2A1 transcription but also inhibit the degradation of SLC2A1 through the RNA-induced silencing complex. As a result, FOXD1 enhances GLUT1 expression and ultimately facilitates PC cell proliferation, invasion, and metastasis by regulating aerobic glycolysis. Taken together, FOXD1 is suggested to be a potential therapeutic target for PC.