【佳学基因检测】质谱成像评估原发性口腔癌及其淋巴结转移的分子瘤内异质性的预后价值

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比较做了备注《Molecules》在. 2022 Aug 25;27(17):5458.发表了一篇题目为《质谱成像评估原发性口腔癌及其淋巴结转移的分子瘤内异质性的预后价值》dota2吧雷电竞 dota2吧雷电竞 治疗基因检测临床研究文章。该研究由Agata Kurczyk, Marta Gawin, Piotr Paul, Ewa Chmielik, Tomasz Rutkowski, Monika Pietrowska, Piotr Widłak 等完成。促进了dota2吧雷电竞 的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

dota2吧雷电竞 预后,头颈部鳞状细胞癌,瘤内异质性,长期结果,质谱成像,肿瘤微环境

肿瘤靶向治疗基因检测临床应用结果

肿瘤内异质性 (ITH) 的不同方面与癌症的发展及其对治疗的反应相关，具有推测的预后价值。在这里，我们寻找通过质谱成像 (MSI) 分析的表型 ITH 与头颈癌预后之间的潜在关联。该研究涉及从 77 名局部晚期口腔鳞状细胞癌患者中切除的组织标本，其中 37 名患者的原发肿瘤和同步淋巴结转移的匹配样本进行了分析。对所有患者进行了 3 年的随访，将他们分为两组：无疾病证据（NED，n = 41）和疾病进展（PD，n = 36）。在组织内胰蛋白酶消化后，所有癌症区域的肽图都使用无监督的方法进行分割，以揭示其内在的异质性。我们发现 PD 组的肿瘤内光谱相似性更高，NED 组在图像分割过程中识别的簇的多样性更高，这表明患者的 ITH 水平更高，结果更有利。与长期结果相关的分子成分的特征可能与参与免疫功能的蛋白质有关。此外，观察到 ITH 与组织病理学淋巴细胞宿主反应之间存在正相关。因此，我们提出在预后较好的癌症中，MSI 显示的 ITH 水平较高可能反映了肿瘤微环境中异型成分的存在，例如浸润免疫细胞增强了对治疗的反应。头颈部鳞状细胞癌；瘤内异质性；长期结果；质谱成像；肿瘤微环境。

肿瘤发生与反复转移国际数据库描述：

Different aspects of intra-tumor heterogeneity (ITH), which are associated with the development of cancer and its response to treatment, have postulated prognostic value. Here we searched for potential association between phenotypic ITH analyzed by mass spectrometry imaging (MSI) and prognosis of head and neck cancer. The study involved tissue specimens resected from 77 patients with locally advanced oral squamous cell carcinoma, including 37 patients where matched samples of primary tumor and synchronous lymph node metastases were analyzed. A 3-year follow-up was available for all patients which enabled their separation into two groups: with no evidence of disease (NED, n = 41) and with progressive disease (PD, n = 36). After on-tissue trypsin digestion, peptide maps of all cancer regions were segmented using an unsupervised approach to reveal their intrinsic heterogeneity. We found that intra-tumor similarity of spectra was higher in the PD group and diversity of clusters identified during image segmentation was higher in the NED group, which indicated a higher level of ITH in patients with more favorable outcomes. Signature of molecular components that correlated with long-term outcomes could be associated with proteins involved in the immune functions. Furthermore, a positive correlation between ITH and histopathological lymphocytic host response was observed. Hence, we proposed that a higher level of ITH revealed by MSI in cancers with a better prognosis could reflect the presence of heterotypic components of tumor microenvironment such as infiltrating immune cells enhancing the response to the treatment.Keywords: cancer prognosis; head and neck squamous cell carcinoma; intratumor heterogeneity; long-term outcome; mass spectrometry imaging; tumor microenvironment.