【佳学基因检测】缺氧诱导的巢蛋白通过靶向转录因子 Nrf2、STAT3 和 SOX2 调节肺癌的活力和代谢

肿瘤基因检测多少钱原理

学习认识到《Comput Intell Neurosci》在. 2022 Aug 30;2022:9811905.发表了一篇题目为《缺氧诱导的巢蛋白通过靶向转录因子 Nrf2、STAT3 和 SOX2 调节肺癌的活力和代谢》肿瘤靶向药物治疗基因检测临床研究文章。该研究由Yongshi Liu, Xinglin Zhang, Tao Jiang, Ning Du 等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

肿瘤靶向治疗基因检测临床应用结果

目的：探讨低氧诱导的Nestin通过靶向转录因子Nrf2、STAT3和SOX2调控肺癌细胞活力和代谢。方法：84例非小细胞肺癌（nonsmall cell lung cancer, NSCLC）治疗2020 年 6 月至 2021 年 2 月，从我们的临床病理学数据库中随机选择。对收集的组织细胞进行免疫组织化学染色，以评估巢蛋白、STAT3、Nrf2 和 SOX2 的表达模式。使用单因素和双因素方差分析对数据进行量化和统计分析，P < 0.05。 Nestin表达与STAT3、Nrf2、SOX2表达相关。Nestin/STAT3/SOX2/Nrf2参与血管生成和肺癌发生发展。结论：缺氧诱导的Nestin通过靶向下游转录因子STAT3促进非小肺癌细胞的进展， Nrf2 和 SOX2。

肿瘤发生与反复转移国际数据库描述：

Objective: To investigate hypoxia-induced Nestin regulates lung cancer viability and metabolism by targeting transcription factors Nrf2, STAT3, and SOX2.Methods: Eighty-four cases of nonsmall cell lung cancer (nonsmall cell lung cancer, NSCLC), which had been treated from June 2020 to February 2021, were randomly selected from our clinicopathology database. Immunohistochemical staining of collected tissue cells was performed to assess the expression patterns of Nestin, STAT3, Nrf2, and SOX2. Data were quantified and statistically analyzed using one-way and two-way ANOVA tests with P < 0.05.Results: Clinicopathological findings showed significant differences in lymph node metastasis, tissue differentiation, and histology on induction of Nestin expression; Nestin expression correlated with STAT3, Nrf2, and SOX2 expression.Nestin/STAT3/SOX2/Nrf2 are involved in angiogenesis and lung cancer development.Conclusion: Hypoxia-induced Nestin promotes the progression of nonsmall lung cancer cells by targeting the downstream transcription factors STAT3, Nrf2, and SOX2.