【佳学基因检测】细胞外囊泡在胶质母细胞瘤发病机制中的新作用

dota2吧雷电竞 基因检测十大公司排序

阅读肿瘤基因解码协会如何提升基因检测的正确性知悉《Metab Brain Dis》在. 2022 Sep 9.发表了一篇题目为《细胞外囊泡在胶质母细胞瘤发病机制中的新作用》肿瘤dota2吧雷电竞 治疗基因检测临床研究文章。该研究由Maryam Khayamzadeh, Vahid Niazi, Bashdar Mahmud Hussen, Mohammad Taheri, Soudeh Ghafouri-Fard, Mohammad Samadian 等完成。促进了肿瘤的正确治疗与个性化用药的发展，进一步强调了基因信息检测与分析的重要性。

肿瘤靶向药物及正确治疗临床研究内容关键词：

生物标志物,表达,细胞外囊泡,胶质母细胞瘤,小RNA

肿瘤靶向治疗基因检测临床应用结果

虽然脑肿瘤并不十分常见，但由于缺乏适当的治疗和发现较晚，它们会导致高死亡率。胶质母细胞瘤是贼常见的原发性脑肿瘤类型。这种恶性肿瘤具有高度侵袭性的行为。已发现不同类型转录物的表达谱、许多基因组基因座的甲基化状态和染色体畸变会影响胶质母细胞瘤的病程以及反复和转移的倾向。贼近的研究表明，胶质母细胞瘤细胞产生细胞外囊泡，其货物可以影响邻近细胞的行为。几种 miRNA，例如 miR-301a、miR-221、miR-21、miR-16、miR-19b、miR-20、miR-26a、miR-92、miR-93、miR-29a、miR-222、miR-已显示 221 和 miR-30a 被胶质母细胞瘤来源的细胞外囊泡转移并增强这些细胞的恶性行为。胶质母细胞瘤衍生的细胞外囊泡的其他成分是 EGFRvIII mRNA/蛋白、Ndfip1、PTEN、MYC ssDNA 和 IDH1 mRNA。在当前的综述中，我们讨论了关于胶质母细胞瘤来源的细胞外囊泡的分子组成及其对这种恶性肿瘤的进展及其对治疗方式的耐药性的影响的现有数据。表达;细胞外囊泡；胶质母细胞瘤；小RNA。

肿瘤发生与反复转移国际数据库描述：

While brain tumors are not extremely frequent, they cause high mortality due to lack of appropriate treatment and late detection. Glioblastoma is the most frequent type of primary brain tumor. This malignant tumor has a highly aggressive behavior. Expression profile of different types of transcripts, methylation status of a number of genomic loci and chromosomal aberrations have been found to affect course of glioblastoma and propensity for recurrence and metastasis. Recent studies have shown that glioblastoma cells produce extracellular vesicles whose cargo can affect behavior of neighboring cells. Several miRNAs such as miR-301a, miR-221, miR-21, miR-16, miR-19b, miR-20, miR-26a, miR-92, miR-93, miR-29a, miR-222, miR-221 and miR-30a have been shown to be transferred by glioblastoma-derived extracellular vesicles and enhance the malignant behavior of these cells. Other components of glioblastoma-derived extracellular vesicles are EGFRvIII mRNA/protein, Ndfip1, PTEN, MYC ssDNA and IDH1 mRNA. In the current review, we discuss the available data about the molecular composition of glioblastoma-derived extracellular vesicles and their impact on the progression of this malignant tumor and its resistance to therapeutic modalities.Keywords: Biomarker; Expression; Extracellular vesicle; Glioblastoma; miRNA.