【佳学基因检测】WNT抑制因子-1的启动子甲基化基因检测与多种dota2吧雷电竞 的发病风险

肿瘤基因检测回扣机会

参加学术会议时，讨论了成人肿瘤与儿童肿瘤基因检测序列的异同点，并在《肿瘤治疗效果与基因检测结果的相关性》的报告中得知《J Cancer Res Ther》在 2018 Jun;14(Supplement):S381-S387发表了一篇题目为《WNT抑制因子-1的启动子甲基化可能与多种人类肿瘤的发病机制有关》肿瘤dota2吧雷电竞 治疗基因检测临床研究文章。该研究由Yong Zhou, Zhaohua Li, Yinlu Ding, Peng Zhang, Jinqing Wang, Jianliang Zhang, Hao Wang 等完成。为肿瘤风险基因检测增加了新的检测位点，选择多肿瘤风险基因解码的全面性再次向前迈进一步。

肿瘤风险基因检测位点的选择及验证关键词：

队列研究, WNT抑制因子-1,荟萃分析,甲基化。

肿瘤风险基因检测的位点选择和验证临床应用结果

多肿瘤风险基因检测位点增加团队的研究目的：多肿瘤风险基因检测位点增加团队使用基于荟萃分析的方法研究了 WNT 抑制因子-1 (WIF-1) 基因甲基化与多种人类肿瘤发病机制的关联。多肿瘤风险基因检测位点增加团队的研究材料和方法：另外采用电子数据库和手动搜索来检索相关的发表的基因解码数据。根据预定义的选择标准筛选与肿瘤和 WIF-1 相关的队列研究，并通过 STATA 软件分析从所选研究中提取的所有数据。多肿瘤风险基因检测位点增加团队的研究结果：多肿瘤风险基因检测位点增加团队的研究贼终纳入了 16 项研究的原始数据，涉及 1112 个肿瘤样本和 612 个相邻正常样品。研究结果表明，肿瘤组织中WIF-1基因甲基化水平明显高于邻近/正常组织。种族亚组分析结果显示，在高加索人、亚洲人和非洲人中，肿瘤组织中WIF-1基因的甲基化状态高于邻近/正常组织。对疾病类型的进一步亚组分析显示，WIF-1 基因甲基化状态是一种普遍现象，即在患有多个人类肿瘤的患者的肿瘤组织中与邻近/正常组织相比观察到。有趣的是，WIF-1基因甲基化基因检测在肺癌、胃癌、星形细胞瘤和邻近/正常组织患者的肿瘤组织之间没有显着差异，表明WIF-1基因甲基化不是一般的非特异性现象。多肿瘤风险基因检测位点增加团队的研究结论：WIF-与邻近正常组织相比，肿瘤组织中的1基因甲基化明显更频繁，表明WIF-1基因甲基化可能是多种人类肿瘤发病机制中的重要事件。可以做为多肿瘤风险基因检测的位点。

肿瘤发生与反复转移国际数据库描述：

Aim: We investigated the association of WNT inhibitory factor-1 (WIF-1) gene methylation with the pathogenesis of multiple human tumors, using a meta-analysis based approach.Materials and methods: Electronic databases and manual search was additionally employed to retrieve relevant published literature. The cohort studies relating to tumor and WIF-1 were screened based on predefined selection criteria, and all extracted data from the selected studies were analyzed through STATA software.Results: Sixteen studies were finally enrolled in our study involved 1112 tumor samples and 612 adjacent normal samples. The study result showed that WIF-1 gene methylations in tumor tissues were significantly higher compared with adjacent/normal tissues. The result of subgroup analysis on ethnicity revealed that in the Caucasians, Asians, and Africans, the methylation status of WIF-1 gene in tumor tissues was higher than adjacent/normal tissues. Further subgroup analysis on disease types revealed that WIF-1 gene methylation status is a widespread phenomenon that is, observed in tumor tissues of patients with multiple human tumors compared with that in adjacent/normal tissues. Interestingly, there was no significant difference in WIF-1 gene methylation between tumor tissues among patients with lung cancer, gastric cancer, astrocytoma, and adjacent/normal tissues, indicating the WIF-1 gene methylation not a general nonspecific phenomenon.Conclusion: WIF-1 gene methylation in tumor tissues was significantly more frequent as compared to that in adjacent normal tissues, indicating that WIF-1 gene methylation may be an important event in the pathogenesis of multiple human tumors.